Metabolites that mark aging are not fully known. We analyze 408 plasma metabolites in
Long Life Family Study participants to characterize markers of age, aging, extreme longevity …

Frailty is characterized by increased vulnerability to disability and high risk for mortality in
older adults. Identification of factors that contribute to frailty resilience is an important step in …

The pursuit of extreme longevity is a popular topic. Advanced technologies such as
metabolomics and proteomics have played a crucial role in unraveling complex molecular …

Apolipoprotein E (APOE) modifies human aging; specifically, the epsilon2 and epsilon4
alleles are among the strongest genetic predictors of longevity and Alzheimer's disease (AD) …

Quantitative trait loci (QTL) denote regions of DNA whose variation is associated with
variations in quantitative traits. QTL discovery is a powerful approach to understand how …

Background: Recent studies have revealed a strong association between the e2 allele of the
Apolipoprotein E (APOE2) gene and lipid metabolites. In addition, APOE2 carriers appear to …

Post-translational modification plays a significant role in the interaction between viruses and
their hosts. The pseudorabies virus (PRV) is a highly contagious herpesvirus that affects the …

Metabolomics technologies enable the quantification of multiple metabolomic measures
simultaneously, which provides novel insights into molecular aspects of human health and …