Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] The gut microbiome, endocannabinoids and metabolic disorders
FA Iannotti, V Di Marzo - Journal of Endocrinology, 2021 - joe.bioscientifica.com
Two complex systems are emerging as being deeply involved in the control of energy
metabolism. The intestinal microbiota, with its warehouse of genes, proteins and small …
metabolism. The intestinal microbiota, with its warehouse of genes, proteins and small …
N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition
N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …
[PDF][PDF] A genome-wide association study discovers 46 loci of the human metabolome in the Hispanic Community Health Study/Study of Latinos
Variation in levels of the human metabolome reflect changes in homeostasis, providing a
window into health and disease. The genetic impact on circulating metabolites in Hispanics …
window into health and disease. The genetic impact on circulating metabolites in Hispanics …
[HTML][HTML] Triglyceride lowering by omega-3 fatty acids: a mechanism mediated by N-acyl taurines
KE Bornfeldt - The Journal of Clinical Investigation, 2021 - Am Soc Clin Investig
Interest in omega-3 fatty acids (colloquially known as fish oils) to lower residual
cardiovascular risk in statin-treated patients has increased markedly in the wake of recent …
cardiovascular risk in statin-treated patients has increased markedly in the wake of recent …
[PDF][PDF] Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice
BD Alrehaili, M Lee, S Takahashi… - Hepatology …, 2022 - Wiley Online Library
Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the
last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia …
last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia …
Function and therapeutic potential of N-acyl amino acids
SA Prakash, RK Kamlekar - Chemistry and physics of lipids, 2021 - Elsevier
N-acyl amino acids (NAAs) are amphiphilic molecules, with different potential fatty acid and
head group moieties. NAAs are the largest family of anandamide congener lipids discovered …
head group moieties. NAAs are the largest family of anandamide congener lipids discovered …
Structure revision of a widespread marine sulfonolipid class based on isolation and total synthesis
D Roman, P Meisinger, R Guillonneau… - Angewandte Chemie …, 2024 - Wiley Online Library
The cosmopolitan marine Roseobacter clade is of global biogeochemical importance.
Members of this clade produce sulfur‐containing amino lipids (SALs) involved in biofilm …
Members of this clade produce sulfur‐containing amino lipids (SALs) involved in biofilm …
[HTML][HTML] Obesity as a Condition determined by Food Addiction: should Brain Endocannabinoid System alterations be the cause and its Modulation the Solution?
Obesity is a complex disorder, and the number of people affected is growing every day. In
recent years, research has confirmed the hypothesis that food addiction is a determining …
recent years, research has confirmed the hypothesis that food addiction is a determining …
[HTML][HTML] An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides
TJ Grevengoed, SAJ Trammell… - The Journal of …, 2021 - Am Soc Clin Investig
Omega-3 fatty acids from fish oil reduce triglyceride levels in mammals, yet the mechanisms
underlying this effect have not been fully clarified, despite the clinical use of omega-3 ethyl …
underlying this effect have not been fully clarified, despite the clinical use of omega-3 ethyl …