Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by
means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Glutathione is the principal intracellular antioxidant buffer against oxidative stress and
mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG) …

Ovarian cancer is one of the most dangerous gynecologic cancers worldwide, showing a
high fatality rate and recurrence due to diagnosis at an advanced stage of the disease and …

Simple Summary Mutations in the tumor suppressor p53 (p53) occur in~ 50% of human
cancers, the majority of which are missense mutations. Mutations in p53 not only impair the …

Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Non-invasive sonodynamic therapy (SDT) was developed because of its advantages of high
penetration depth and low side effects; however, tumor hypoxia greatly restricts its …

Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that
affect the nervous system and heart, all of which are vital to the human body. To maintain …