The maintenance and preservation of distinct phases during the cell cycle is a highly
complex and coordinated process. It is regulated by phosphorylation—through the activity of …

The SCF (Skp1, Cullins, F-box proteins) multisubunit E3 ubiquitin ligase, also known as CRL
(Cullin-RING ubiquitin Ligase) is the largest E3 ubiquitin ligase family that promotes the …

S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-
Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle dysregulation and …

The expression of Skp2, the ubiquitin ligase subunit that targets p27Kip1 for degradation, is
commonly overexpressed in human cancers. p27Kip1 is a negative regulator of the cell …

This study focused on a cell cycle regulatory gene, FBXW7, which ubiquitinates c‐Myc and
cyclin E and promotes exit from the cell cycle. We determined the expression level of FBXW7 …

Background: Breast cancer is the most common female malignant disease, and the second
leading cause of cancer-related death in the United States. Acquired resistance to …

Background The mechanism underlying the differential cytotoxicity of curcumin in various
cancer types, however, remains largely unclear. The aims of this study is to examine the …

Mechanical tensions are usually generated during development at spatially defined regions
within tissues. Such physical cues dictate the cellular decisions of proliferation or cell cycle …

Introduction Triple-negative breast cancer (TNBC) high rate of relapse is thought to be due
to the presence of tumor-initiating cells (TICs), molecularly defined as being CD44 …

This study consisted of 2 aims:(i) to determine genes associated with hepatocellular
carcinoma (HCC) by microarray analysis; and (ii) to evaluate the clinicopathological …