Human brain organoids are three-dimensional tissues that are generated in vitro from
pluripotent stem cells and recapitulate the early development of the human brain. Brain …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Advances in the field of human stem cells are often a source of public and ethical
controversy. Researchers must frequently balance diverse societal perspectives on …

Summary Serotonin (5-HT) neurons, the major components of the raphe nuclei, arise from
ventral hindbrain progenitors. Based on anatomical location and axonal projection, 5-HT …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Current protocols for producing cerebellar neurons from human pluripotent stem cells
(hPSCs) often rely on animal co-culture and mostly exist as monolayers, limiting their …

Region specific brain organoids are brain organoids derived by patterning protocols using
extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main …

Background The first human brain organoid protocol was presented in the beginning of the
previous decade, and since then, the field witnessed the development of many new brain …

Engineered three-dimensional (3D) in vitro and ex vivo neural tissues, also known as “mini
brains and spinal cords in a dish,” can be derived from different types of human stem cells …

Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex
human tissues that recapitulate features of architecture, composition and function of in vivo …