Cardiovascular disease is a leading cause of death worldwide and there is a pressing need
for new therapeutic strategies to treat such conditions. The risk of developing cardiovascular …

Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …

Mineralocorticoid receptor antagonists (MRAs) reduce morbidity and mortality in chronic
heart failure. Novel nonsteroidal MRAs are currently developed and need to be …

Cardiac fibrosis are central to various cardiovascular diseases. Research on the
mechanisms and therapeutic targets for cardiac fibrosis has advanced greatly in recent …

Abstract Cancer-associated fibroblasts (CAFs), are the key effector cells in pancreatic ductal
adenocarcinoma (PDAC), known to induce tumor growth and progression. Pancreatic …

Fibrosis refers to the hardening or scarring of tissues that usually results from aberrant
wound healing in response to organ injury, and its manifestations in various organs have …

Fibrosis contributes to the development of many diseases and many target molecules are
involved in fibrosis. Currently, the majority of fibrosis treatment strategies are limited to …

Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and
anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval …

The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …

Aim: Gut microbiota is of crucial importance to cardiac health. Astragaloside IV (AS-IV) is a
main active ingredient of Huangqi, a traditional edible and medicinal herb that has been …