Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur
after the administration of local anesthetic drugs through a variety of routes. Increasing use …

Abstract The American Society of Regional Anesthesia and Pain Medicine's Third Practice
Advisory on local anesthetic systemic toxicity is an interim update from its 2010 advisory …

Despite advances in clinical practice, local anaesthetic systemic toxicity continues to occur
with the therapeutic use of local anaesthesia. Patterns of presentation have evolved over …

Introduction Emergency clinicians utilize local anesthetics for a variety of procedures in the
emergency department (ED) setting. Local anesthetic systemic toxicity (LAST) is a potentially …

The experimental use of lipid emulsion for local anesthetic toxicity was originally identified in
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …

Lipid emulsion has been shown to be an effective treatment for systemic toxicity induced by
local anesthetics, which is reflected in case reports. A systemic review and meta-analysis …

Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST).
LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local …

Triglyceride micro-emulsions such as Intralipid® have been used to reverse cardiac toxicity
induced by a number of drugs but reservations about their broad-spectrum applicability …

Well-placed local anaesthetics (LAs) can yield great clinical benefits. But systemic toxicity
related to their use can be devastating. The highly publicized case in 2004 of Mayra …

Biodetoxification using intravenous lipid emulsion (ILE) in acute poisoning is of growing
interest. As well as for local anesthetics, ILE is currently used to reverse toxicity caused by a …