Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Background Critical examination of the quality and validity of available allergic rhinitis (AR)
literature is necessary to improve understanding and to appropriately translate this …

BACKGROUND: Allergic rhinitis represents a global health problem affecting 10% to 20% of
the population. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines have been …

Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …

While the term asthma has long been known to describe heterogeneous groupings of
patients, only recently have data evolved which enable a molecular understanding of the …

Patients with allergic rhinitis have traditionally been placed into 'seasonal'and
'perennial'categories, which do not account for the subclinical inflammatory state that exists …

Background In severe asthmatics with persistent airway eosinophilia, blockade of interleukin‐
5 has significant steroid‐sparing effects and attenuates blood and sputum eosinophilia. The …

Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in
severe, treatment-refractory disease. Applying mass cytometry and machine learning to …

The upper and lower airways are linked from anatomical, histological, and immunological
perspectives and form a united airways system with inflammation in one part of the airways …

Background TPI ASM8 contains two modified phosphorothioate antisense oligonucleotides
(AON), one targeting the common beta chain (βc) of the IL‐3/IL‐5/GM‐CSF receptors and …