[HTML][HTML] Overview of the 2022 WHO classification of adrenal cortical tumors
The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …
[HTML][HTML] Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
[HTML][HTML] Signatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
Targeted protein degradation: expanding the toolbox
M Schapira, MF Calabrese, AN Bullock… - Nature reviews Drug …, 2019 - nature.com
Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted
protein degradation by the ubiquitin–proteasome system represent a new therapeutic …
protein degradation by the ubiquitin–proteasome system represent a new therapeutic …
[HTML][HTML] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
KA Hoadley, C Yau, T Hinoue, DM Wolf, AJ Lazar… - Cell, 2018 - cell.com
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
[HTML][HTML] Machine learning identifies stemness features associated with oncogenic dedifferentiation
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
Landscape of microsatellite instability across 39 cancer types
Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
Integrative molecular characterization of malignant pleural mesothelioma
J Hmeljak, F Sanchez-Vega, KA Hoadley, J Shih… - Cancer discovery, 2018 - AACR
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest
cavity. To expand our understanding of MPM, we conducted a comprehensive integrated …
cavity. To expand our understanding of MPM, we conducted a comprehensive integrated …
[HTML][HTML] UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses
DS Chandrashekar, B Bashel, SAH Balasubramanya… - Neoplasia, 2017 - Elsevier
Abstract Genomics data from The Cancer Genome Atlas (TCGA) project has led to the
comprehensive molecular characterization of multiple cancer types. The large sample …
comprehensive molecular characterization of multiple cancer types. The large sample …