[HTML][HTML] SARS-CoV-2 Omicron-B. 1.1. 529 leads to widespread escape from neutralizing antibody responses
On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B. 1.1.
529 was announced, containing far more mutations in Spike (S) than previously reported …
529 was announced, containing far more mutations in Spike (S) than previously reported …
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
The COVID-19 pandemic has had an unprecedented health and economic impact and there
are currently no approved therapies. We have isolated an antibody, EY6A, from an …
are currently no approved therapies. We have isolated an antibody, EY6A, from an …
Fragment-based screening using X-ray crystallography and NMR spectroscopy
H Jhoti, A Cleasby, M Verdonk, G Williams - Current opinion in chemical …, 2007 - Elsevier
Approaches which start from a study of the interaction of very simple molecules (fragments)
with the protein target are proving to be valuable additions to drug design. Fragment-based …
with the protein target are proving to be valuable additions to drug design. Fragment-based …
Immunoglobulin superfamily cell adhesion molecules: zippers and signals
AR Aricescu, EY Jones - Current opinion in cell biology, 2007 - Elsevier
The latest structural studies of immunoglobulin superfamily cell adhesion molecules are
driving a shift in perspective; increasingly the view is not focused solely on the individual …
driving a shift in perspective; increasingly the view is not focused solely on the individual …
Crystal structure of a human GABAA receptor
PS Miller, AR Aricescu - Nature, 2014 - nature.com
Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
[HTML][HTML] Neutralization of SARS-CoV-2 by destruction of the prefusion spike
There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …
Structures of influenza A virus RNA polymerase offer insight into viral genome replication
Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from
the transmission of novel zoonotic influenza A viruses to humans,. Influenza A viruses …
the transmission of novel zoonotic influenza A viruses to humans,. Influenza A viruses …
[PDF][PDF] A time-and cost-efficient system for high-level protein production in mammalian cells
AR Aricescu, W Lu, EY Jones - Acta Crystallographica Section D …, 2006 - journals.iucr.org
Most proteins for structural biology studies are produced by high-level expression in
Escherichia coli. However, prokaryotic based expression systems fail to generate correctly …
Escherichia coli. However, prokaryotic based expression systems fail to generate correctly …
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
Abstract Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children
that can cause severe central nervous system disease and death. No vaccine or antiviral …
that can cause severe central nervous system disease and death. No vaccine or antiviral …
Toremifene interacts with and destabilizes the Ebola virus glycoprotein
Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including
the recent deadly epidemic in West Africa. There are currently no approved therapeutic …
the recent deadly epidemic in West Africa. There are currently no approved therapeutic …