Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

Since the recent discovery of the mechanosensitive Piezo1 channels, many studies have
addressed the role of the channel in various physiological or even pathological processes of …

Hemodynamic overload and dysregulation of cellular metabolism are involved in
development of calcific aortic valve disease (CAVD). However, how mechanical stress …

Cardiovascular diseases caused by atherosclerosis (AS) seriously endanger human health,
which is closely related to vascular smooth muscle cell (VSMC) phenotypes. VSMC …

Ethnopharmacological relevance Panax notoginseng saponins (PNS) are the major
effective components of Panax notoginseng (burk) FH Chen which is one of the classic …

All animal cells control their volume through a complex set of mechanisms, both to
counteract osmotic perturbations of the environment and to enable numerous vital biological …

PIEZO1 is a eukaryotic membrane protein that assembles as trimers to form calcium‐
permeable, non‐selective cation channels with exquisite capabilities for mechanical force …

The cation channel Piezo1, a crucial mechanotransducer found in various organs and
tissues, has gained considerable attention as a therapeutic target in recent years. Following …

Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating
mechanical stimuli into biological signaling. Its involvement extends beyond physiological …

Cardiovascular calcification, characterized by hydroxyapatite deposition in the arterial wall
and heart valves, is associated with high cardiovascular morbidity and mortality …