Excessive folic acid intake and relation to adverse health outcome
J Selhub, IH Rosenberg - Biochimie, 2016 - Elsevier
The recent increase in the intake of folic acid by the general public through fortified foods
and supplements, has raised safety concern based on early reports of adverse health …
and supplements, has raised safety concern based on early reports of adverse health …
Dietary modulation of the epigenome
FY Ideraabdullah, SH Zeisel - Physiological reviews, 2018 - journals.physiology.org
Epigenetics is the study of heritable mechanisms that can modify gene activity and
phenotype without modifying the genetic code. The basis for the concept of epigenetics …
phenotype without modifying the genetic code. The basis for the concept of epigenetics …
[HTML][HTML] High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
KE Christensen, LG Mikael, KY Leung… - The American journal of …, 2015 - Elsevier
Background: Increased consumption of folic acid is prevalent, leading to concerns about
negative consequences. The effects of folic acid on the liver, the primary organ for folate …
negative consequences. The effects of folic acid on the liver, the primary organ for folate …
[HTML][HTML] High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood
L Plumptre, SP Masih, A Ly, S Aufreiter, KJ Sohn… - The American journal of …, 2015 - Elsevier
Background: Mandatory fortification, prevalent supplement use, and public health guidelines
recommending periconceptional supplementation have increased folic acid intakes in North …
recommending periconceptional supplementation have increased folic acid intakes in North …
Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation
STUDY QUESTION Do paternal exposures to folic acid deficient (FD), and/or folic acid
supplemented (FS) diets, throughout germ cell development adversely affect male germ …
supplemented (FS) diets, throughout germ cell development adversely affect male germ …
Canadian consensus on female nutrition: adolescence, reproduction, menopause, and beyond
DL O'Connor, J Blake, R Bell, A Bowen… - Journal of Obstetrics and …, 2016 - Elsevier
Canadian Consensus on Female Nutrition: Adolescence, Reproduction, Menopause, and
Beyond - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …
Beyond - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …
[HTML][HTML] High folate and low vitamin B-12 intakes during pregnancy are associated with small-for-gestational age infants in South Indian women: a prospective …
P Dwarkanath, JR Barzilay, T Thomas… - The American journal of …, 2013 - Elsevier
Background: Folic acid supplementation in those with a low vitamin B-12 intake or status
may have adverse effects. These effects are unknown with regard to birth outcome in …
may have adverse effects. These effects are unknown with regard to birth outcome in …
Folic acid supplements during pregnancy and child psychomotor development after the first year of life
D Valera-Gran, MG de la Hera… - JAMA …, 2014 - jamanetwork.com
Importance Folate intake during pregnancy has been associated with improved
neuropsychological development in children, although the effects of high dosages of folic …
neuropsychological development in children, although the effects of high dosages of folic …
[HTML][HTML] Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4–5 y of age: the prospective birth cohort Infancia y …
D Valera-Gran, EM Navarrete-Munoz… - The American journal of …, 2017 - Elsevier
Background The benefits of the use of folic acid supplements (FASs) during the
periconception period to prevent neural tube defects and to ensure normal brain …
periconception period to prevent neural tube defects and to ensure normal brain …
Increasing maternal or post-weaning folic acid alters gene expression and moderately changes behavior in the offspring
S Barua, KK Chadman, S Kuizon, D Buenaventura… - PLoS …, 2014 - journals.plos.org
Background Studies have indicated that altered maternal micronutrients and vitamins
influence the development of newborns and altered nutrient exposure throughout the …
influence the development of newborns and altered nutrient exposure throughout the …