Excessive folic acid intake and relation to adverse health outcome

J Selhub, IH Rosenberg - Biochimie, 2016 - Elsevier
The recent increase in the intake of folic acid by the general public through fortified foods
and supplements, has raised safety concern based on early reports of adverse health …

Dietary modulation of the epigenome

FY Ideraabdullah, SH Zeisel - Physiological reviews, 2018 - journals.physiology.org
Epigenetics is the study of heritable mechanisms that can modify gene activity and
phenotype without modifying the genetic code. The basis for the concept of epigenetics …

[HTML][HTML] High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice

KE Christensen, LG Mikael, KY Leung… - The American journal of …, 2015 - Elsevier
Background: Increased consumption of folic acid is prevalent, leading to concerns about
negative consequences. The effects of folic acid on the liver, the primary organ for folate …

[HTML][HTML] High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood

L Plumptre, SP Masih, A Ly, S Aufreiter, KJ Sohn… - The American journal of …, 2015 - Elsevier
Background: Mandatory fortification, prevalent supplement use, and public health guidelines
recommending periconceptional supplementation have increased folic acid intakes in North …

Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation

L Ly, D Chan, M Aarabi, M Landry… - MHR: Basic science …, 2017 - academic.oup.com
STUDY QUESTION Do paternal exposures to folic acid deficient (FD), and/or folic acid
supplemented (FS) diets, throughout germ cell development adversely affect male germ …

Canadian consensus on female nutrition: adolescence, reproduction, menopause, and beyond

DL O'Connor, J Blake, R Bell, A Bowen… - Journal of Obstetrics and …, 2016 - Elsevier
Canadian Consensus on Female Nutrition: Adolescence, Reproduction, Menopause, and
Beyond - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

[HTML][HTML] High folate and low vitamin B-12 intakes during pregnancy are associated with small-for-gestational age infants in South Indian women: a prospective …

P Dwarkanath, JR Barzilay, T Thomas… - The American journal of …, 2013 - Elsevier
Background: Folic acid supplementation in those with a low vitamin B-12 intake or status
may have adverse effects. These effects are unknown with regard to birth outcome in …

Folic acid supplements during pregnancy and child psychomotor development after the first year of life

D Valera-Gran, MG de la Hera… - JAMA …, 2014 - jamanetwork.com
Importance Folate intake during pregnancy has been associated with improved
neuropsychological development in children, although the effects of high dosages of folic …

[HTML][HTML] Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4–5 y of age: the prospective birth cohort Infancia y …

D Valera-Gran, EM Navarrete-Munoz… - The American journal of …, 2017 - Elsevier
Background The benefits of the use of folic acid supplements (FASs) during the
periconception period to prevent neural tube defects and to ensure normal brain …

Increasing maternal or post-weaning folic acid alters gene expression and moderately changes behavior in the offspring

S Barua, KK Chadman, S Kuizon, D Buenaventura… - PLoS …, 2014 - journals.plos.org
Background Studies have indicated that altered maternal micronutrients and vitamins
influence the development of newborns and altered nutrient exposure throughout the …