The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
S Datta, M Cano, K Ebrahimi, L Wang… - Progress in retinal and …, 2017 - Elsevier
The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
Complement and its role in innate and adaptive immune responses
JR Dunkelberger, WC Song - Cell research, 2010 - nature.com
The complement system plays a crucial role in the innate defense against common
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …
Complement control protein factor H: the good, the bad, and the inadequate
VP Ferreira, MK Pangburn, C Cortés - Molecular immunology, 2010 - Elsevier
The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …
participates in elimination of pathogens and altered host cells and comprises an essential …
The human complement factor H: functional roles, genetic variations and disease associations
SR de Córdoba, J Esparza-Gordillo, EG de Jorge… - Molecular …, 2004 - Elsevier
Factor H is an essential regulatory protein that plays a critical role in the homeostasis of the
complement system in plasma and in the protection of bystander host cells and tissues from …
complement system in plasma and in the protection of bystander host cells and tissues from …
The central role of the alternative complement pathway in human disease
JM Thurman, VM Holers - The Journal of Immunology, 2006 - journals.aai.org
The complement system is increasingly recognized as important in the pathogenesis of
tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement …
tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement …
Complement in health and disease
MV Carroll, RB Sim - Advanced drug delivery reviews, 2011 - Elsevier
The complement system consists of about 35–40 proteins and glycoproteins present in
blood plasma or on cell surfaces. Its main biological function is to recognise “foreign” …
blood plasma or on cell surfaces. Its main biological function is to recognise “foreign” …
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome
A Richards, EJ Kemp, MK Liszewski… - Proceedings of the …, 2003 - National Acad Sciences
Membrane cofactor protein (MCP; CD46) is a widely expressed transmembrane
complement regulator. Like factor H it inhibits complement activation by regulating C3b …
complement regulator. Like factor H it inhibits complement activation by regulating C3b …
On phagocytes and macular degeneration
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …
interplay of age and genetic and environmental risk factors. A common feature observed in …
Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H
SR De Córdoba, EG De Jorge - Clinical & Experimental …, 2008 - academic.oup.com
Summary OTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW
SERIES ON COMPLEMENT FACTOR H Structural and functional correlations for factor H …
SERIES ON COMPLEMENT FACTOR H Structural and functional correlations for factor H …