Glioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors,
characterized by malignant growth, invasion into the brain parenchyma, and resistance to …

One of the most common brain tumors in children and adults is glioma or astrocytoma. There
are few effective therapies for these cancers, and patients with malignant glioma fare poorly …

Inflammatory processes and microglia activation accompany most of the pathophysiological
diseases in the central nervous system. It is proven that glial pathology precedes and even …

2-Deoxy-2-[18F] fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet
whether these cells contribute to cognitive deficits and secondary inflammatory pathology …

Microglia are resident myeloid cells in the central nervous system (CNS) that control
homeostasis and protect CNS from damage and infections. Microglia and peripheral …

Despite a deeper molecular understanding, human glioblastoma remains one of the most
treatment refractory and fatal cancers. It is known that the presence of macrophages and …

Cellular and non-cellular components of the tumor microenvironment (TME) are emerging
as key regulators of primary tumor progression, organ-specific metastasis, and therapeutic …

Microglia, once viewed as static bystanders with limited homeostatic functions, are now
considered key players in the development of neuroinflammatory and neurodegenerative …