Mechanisms and consequences of intestinal dysbiosis
GA Weiss, T Hennet - Cellular and Molecular Life Sciences, 2017 - Springer
The composition of the gut microbiota is in constant flow under the influence of factors such
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …
Bacterial flagellin—a potent immunomodulatory agent
Flagellin is a subunit protein of the flagellum, a whip-like appendage that enables bacterial
motility. Traditionally, flagellin was viewed as a virulence factor that contributes to the …
motility. Traditionally, flagellin was viewed as a virulence factor that contributes to the …
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination
JZ Oh, R Ravindran, B Chassaing, FA Carvalho… - Immunity, 2014 - cell.com
Systems biological analysis of immunity to the trivalent inactivated influenza vaccine (TIV) in
humans revealed a correlation between early expression of TLR5 and the magnitude of the …
humans revealed a correlation between early expression of TLR5 and the magnitude of the …
Mucosal vaccines: the promise and the challenge
MR Neutra, PA Kozlowski - Nature reviews immunology, 2006 - nature.com
Most infectious agents enter the body at mucosal surfaces and therefore mucosal immune
responses function as a first line of defence. Protective mucosal immune responses are most …
responses function as a first line of defence. Protective mucosal immune responses are most …
A self-assembling peptide acting as an immune adjuvant
The development of vaccines and other immunotherapies has been complicated by
heterogeneous antigen display and the use of incompletely defined immune adjuvants with …
heterogeneous antigen display and the use of incompletely defined immune adjuvants with …
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
Abstract Toll-like receptor 5 (TLR5) recognizes bacterial flagellin and activates host
inflammatory responses. In this study, we examine the nature of the TLR5-flagellin …
inflammatory responses. In this study, we examine the nature of the TLR5-flagellin …
Bacterial flagellin is a dominant antigen in Crohn disease
Chronic intestinal inflammation, as seen in inflammatory bowel disease (IBD), results from
an aberrant and poorly understood mucosal immune response to the microbiota of the …
an aberrant and poorly understood mucosal immune response to the microbiota of the …
Evasion of Toll-like receptor 5 by flagellated bacteria
E Andersen-Nissen, KD Smith… - Proceedings of the …, 2005 - National Acad Sciences
Toll-like receptor 5 (TLR5) recognizes an evolutionarily conserved site on bacterial flagellin
that is required for flagellar filament assembly and motility. The α and ε Proteobacteria …
that is required for flagellar filament assembly and motility. The α and ε Proteobacteria …
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated …
Dendritic cells (DCs) are pivotal in determining the class of an adaptive immune response.
However, the molecular mechanisms within DCs that determine this decision-making …
However, the molecular mechanisms within DCs that determine this decision-making …
Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa
Flagella contribute to the virulence of pathogenic bacteria through chemotaxis, adhesion to
and invasion of host surfaces. Flagellin is the structural protein that forms the major portion …
and invasion of host surfaces. Flagellin is the structural protein that forms the major portion …