Most societies witness an ever increasing prevalence of both obesity and dementia, a
scenario related to often underestimated individual and public health burden. Overnutrition …

Bariatric surgery results in long-term weight loss and an improved metabolic phenotype due
to changes in the gut-brain axis regulating appetite and glycaemia. Neuroendocrine …

Objective The hypothalamus is the main integrator of peripheral and central signals in the
control of energy homeostasis. Its functional relevance for the effectivity of bariatric surgery is …

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut
microbiome modulates levels of BAs. We systematically explore the host genetic, gut …

Background Metabolic disorders associated with obesity could lead to alterations in brain
structure and function. Whether these changes can be reversed after weight loss is unclear …

Background MRI studies show that obese adults have reduced grey matter (GM) and white
matter (WM) tissue density as well as altered WM integrity. Bariatric surgery can lead to …

Abstract Changes in eating behaviour including reductions in appetite and food intake, and
healthier food cue reactivity, reward, hedonics and potentially also preference, contribute to …

Purpose Roux-en-Y gastric bypass (RYGB) surgery produces significant weight loss.
However, a number of patients experience weight regain years after surgery. Factors driving …

Background Obesity has been associated with depressive symptoms and impaired
cognition, but the mechanisms underlying these relationships are not well understood. It is …

Recent evidence showed that DNA methylation changes can contribute substantially to body
weight regulation, as well as modulate expression of appetite and satiety genes, controlling …