Laboratory assessment of the anticoagulant activity of direct oral anticoagulants: a systematic review

BT Samuelson, A Cuker, DM Siegal, M Crowther… - Chest, 2017 - Elsevier
Background Direct oral anticoagulants (DOACs) are the treatment of choice for most patients
with atrial fibrillation and/or noncancer-associated venous thromboembolic disease …

Laboratory measurement of the anticoagulant activity of the non–vitamin K oral anticoagulants

A Cuker, DM Siegal, MA Crowther, DA Garcia - Journal of the American …, 2014 - jacc.org
Background: Non–vitamin K oral anticoagulants (NOACs) do not require routine laboratory
monitoring. However, laboratory measurement may be desirable in special situations and …

[HTML][HTML] International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of direct oral anticoagulants

RC Gosselin, DM Adcock, SM Bates… - Thrombosis and …, 2018 - thieme-connect.com
This guidance document was prepared on behalf of the International Council for
Standardization in Haematology (ICSH) for providing haemostasis-related guidance …

Apixaban pharmacokinetics at steady state in hemodialysis patients

TA Mavrakanas, CF Samer, SJ Nessim… - Journal of the …, 2017 - journals.lww.com
It is unclear whether warfarin is protective or harmful in patients with ESRD and atrial
fibrillation. This state of equipoise raises the question of whether alternative anticoagulants …

Reversal agents for non-vitamin K antagonist oral anticoagulants

JH Levy, J Douketis, JI Weitz - Nature Reviews Cardiology, 2018 - nature.com
The non-vitamin K antagonist oral anticoagulants (NOACs) include dabigatran, which
inhibits thrombin, and apixaban, betrixaban, edoxaban, and rivaroxaban, which inhibit …

Predictors of pre-procedural concentrations of direct oral anticoagulants: a prospective multicentre study

A Godier, AS Dincq, AC Martin, A Radu… - European heart …, 2017 - academic.oup.com
Aims Patients receiving direct oral anticoagulants (DOACs) frequently undergo elective
invasive procedures. Their management is challenging. We aimed to determine the optimal …

[HTML][HTML] Perioperative management of patients on direct oral anticoagulants

V Dubois, AS Dincq, J Douxfils, B Ickx, CM Samama… - Thrombosis …, 2017 - Springer
Direct oral anticoagulants (DOACs) have been licensed worldwide for several years for
various indications. Each year, 10–15% of patients on oral anticoagulants will undergo an …

Recent guidelines and recommendations for laboratory assessment of the direct oral anticoagulants (DOACs): is there consensus?

G Lippi, EJ Favaloro - Clinical Chemistry and Laboratory Medicine …, 2015 - degruyter.com
A new generation of antithrombotic agents, which are conventionally known as direct oral
anticoagulants (DOACs), have recently emerged and are continuing to be developed. These …

[HTML][HTML] Laboratory Testing in the era of Direct or non–vitamin K antagonist oral anticoagulants: a practical guide to measuring their activity and avoiding diagnostic …

EJ Favaloro, G Lippi - Seminars in thrombosis and hemostasis, 2015 - thieme-connect.com
A new generation of antithrombotic agents has recently emerged. These provide direct
inhibition of either thrombin (factor IIa [FIIa]) or FXa, and are increasingly replacing the …

Laboratory measurement of the direct oral anticoagulants

BJ Dale, NC Chan… - British journal of …, 2016 - Wiley Online Library
Direct oral anticoagulants (DOAC s), including the direct thrombin inhibitor, dabigatran, and
the direct factor Xa (FX a) inhibitors, rivaroxaban, apixaban and edoxaban, are approved for …