Background Insulin resistance is a critical cause of metabolic dysfunctions. Metabolic
dysfunction is common in patients with cancer and is associated with higher cancer …

There are nearly 17 million cancer survivors in the United States, including those who are
currently receiving cancer therapy with curative intent and expected to be long-term …

Importance Diabetes is an established risk factor for developing cancer. A limited body of
evidence also suggests that cancer can increase the risk of developing new cases of …

Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …

Over the last two decades, increased availability of human pancreatic tissues has allowed
for major expansions in our understanding of islet biology in health and disease. Indeed …

Background Although hyperglycemia and pancreatitis are known side effects of L-
asparaginase, both contributing to the development of diabetic ketoacidosis (DKA) is …

Type 2 diabetes mellitus and breast cancer are complex, chronic, heterogeneous, and multi-
factorial diseases; with common risk factors including but not limited to diet, obesity, and …

Background Diabetes is considered as an established risk factor for cancer development.
However, the link between diabetes among cancer survivors remains inconclusive. The …

Recent studies have focused on identifying novel targeted agents in order to reduce the
undesired side‑effects of conventional chemotherapeutic agents on normal cells. However …

Background Breast cancer chemotherapy with high dose alkylating agents is severely
limited by their collateral toxicity to crucial normal tissues such as immune and gut cells …