Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …

Multiple myeloma (MM) is a disease that affects plasma cells and can lead to devastating
clinical features such as anemia, lytic bone lesions, hypercalcemia, and renal disease. An …

Multiple myeloma (MM) is a plasma-cell malignancy which remains incurable despite the
recent emergence of multiple novel agents. Importantly, recent genetic and molecular …

Chemical probes represent an important component of both academic and pharmaceutical
drug discovery research. As a complement to prior reviews that have defined this scientific …

Cancer immunotherapies are dramatically reshaping the clinical management of oncologic
patients. For many of these therapies, the guidelines for administration, monitoring, and …

Survival for patients with multiple myeloma has significantly improved in the last decade in
large part due to the development of proteasome inhibitors and immunomodulatory drugs …

Individuals with a PTEN germline mutation receive the molecular diagnosis of PTEN
hamartoma tumor syndrome (PHTS). PHTS displays a complex spectrum of clinical …

Multiple Myeloma (MM) is a malignant plasma cell disorder with an unmet medical need, in
particular for relapsed and refractory patients. Molecules within deregulated signaling …

The therapy of breast cancer is encumbered by drug resistance and metastasis, which can
be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at …

The main anti-diabetic effect of metformin mediated through stimulation of adenosine
monophosphate (AMP)-activated protein kinase (AMPK) is the inhibition of hepatic …