The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

Cancer genomics studies have identified thousands of putative cancer driver genes.
Development of high-throughput and accurate models to define the functions of these genes …

INTRODUCTION Cancer progression is fundamentally an evolutionary process, involving
multiple distinct steps from oncogenic transformation to metastatic dissemination to …

Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication.
Any two randomly selected cells, whether normal or cancerous, are therefore genetically …

Tumor initiation and progression are somatic evolutionary processes driven by the
accumulation of genetic alterations, some of which confer selective fitness advantages to the …

In the past decade, the development of a genome-editing technology mediated by CRISPR
has made genetic engineering easier than ever, both in vitro and in vivo. CRISPR systems …

Immunocyte infiltration and cytotoxicity play critical roles in both inflammation and
immunotherapy. However, current cancer immunotherapy screening methods overlook the …

Recent progress in understanding the molecular basis of cellular processes, identification of
promising therapeutic targets and evolution of the regulatory landscape makes this an …