Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …

Malaria is an endemic disease, prevalent in tropical and subtropical regions which cost half
of million deaths annually. The eradication of malaria is one of the global health priority …

Quinoline, a privileged scaffold in medicinal chemistry, has always been associated with a
multitude of biological activities. Especially in antimalarial and anticancer research …

Among the variety of sulfonamides, triflamides (CF3SO2NHR, TfNHR) occupy a special
position in organic chemistry. Triflamides are widely used as reagents, efficient catalysts or …

Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …

Neglected tropical diseases (NTDs) affect mainly poor and marginalized populations of
tropical and subtropical areas in 150 countries. Many of the chemical processes involved in …

Hydroxyquinoline (HQ) is alkylated with the suitable di-substituted butane, such as 1-Bromo-
4 Chlorobutane (BCB), to produce a Chloro and Bromobutoxyquinoline (key intermediate of …

To identity fast-acting, multistage antimalarial agents, a series of pyridylvinylquinoline-
triazole analogues have been synthesized via CuAAC. Most of the compounds display …

Diffuse gastric cancer and lobular breast cancer are aggressive malignancies that are
frequently associated with inactivating mutations in the tumor suppressor gene CDH1 …

The quinoline moiety is a privileged scaffold among heterocyclic compounds that is an
important construction motif in the fields of pharmaceutical chemistry. Quinoline molecule …