Due to their high reaction rate and reliable selectivity, bioorthogonal click reactions have
been extensively investigated in numerous research fields, such as nanotechnology, drug …

Simple Summary Melanoma is a very aggressive and fatal malignant tumor. While curable if
diagnosed in its early stages, advanced melanoma, despite the complex therapeutic …

Targeted alpha‐therapy (TAT) has great potential for treating a broad range of late‐stage
cancers by delivering a focused and lethal radiation dose to tumors. Actinium‐225 (225Ac) …

Radiolabeled peptides have emerged as highly specific agents for targeting receptors
expressed in tumors for therapeutic and diagnostic purposes. Peptides developed for …

The stabilization of peptide secondary structure via stapling is a ubiquitous goal for creating
new probes, imaging agents, and drugs. Inspired by indole‐derived crosslinks found in …

The nuclear decay characteristics of 225Ac (E α= 5–8 MeV, linear energy transfer (LET)=∼
100 keV/μm, t 1/2= 9.92 days) are well recognized as advantageous for the treatment of …

Melanocortin-1 receptor (MC1R) and very late antigen-4 (VLA-4, integrin α4β1) are 2
attractive molecular targets for developing peptide radiopharmaceuticals for melanoma …

The concept of positron emission tomography (PET) based imaging was developed more
than 40 years ago. It has been a widely adopted technique for detecting and staging …

DOTA is commonly used for radiometal chelation in molecular imaging. Yet in the absence
of a radiometal, DOTA is hypothesized to promote renal clearance of 18F-labeled peptide …

With peptides increasingly favored as drugs, natural product motifs, namely the
tryptathionine staple, found in amatoxins and phallotoxins, and the 2, 2'‐bis‐indole found in …