Pathogenesis and virulence of flavivirus infections

SW van Leur, T Heunis, D Munnur, S Sanyal - Virulence, 2021 - Taylor & Francis
The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …

Decoding Toll-like receptors: Recent insights and perspectives in innate immunity

T Kawai, M Ikegawa, D Ori, S Akira - Immunity, 2024 - cell.com
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

S Denolly, A Stukalov, U Barayeu, AN Rosinski… - Nature …, 2023 - nature.com
Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a
vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close …

Role of toll-like receptors in neuroimmune diseases: Therapeutic targets and problems

H Li, S Liu, J Han, S Li, X Gao, M Wang, J Zhu… - Frontiers in …, 2021 - frontiersin.org
Toll-like receptors (TLRs) are a class of proteins playing a key role in innate and adaptive
immune responses. TLRs are involved in the development and progression of neuroimmune …

Immune–epithelial cell cross‐talk enhances antiviral responsiveness to SARS‐CoV‐2 in children

VG Magalhães, S Lukassen, M Drechsler, J Loske… - EMBO …, 2023 - embopress.org
The risk of developing severe COVID‐19 rises dramatically with age. Schoolchildren are
significantly less likely than older people to die from SARS‐CoV‐2 infection, but the …

High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response

SS Burkart, D Schweinoch, J Frankish… - Life Science …, 2023 - life-science-alliance.org
RIG-I recognizes viral dsRNA and activates a cell-autonomous antiviral response. Upon
stimulation, it triggers a signaling cascade leading to the production of type I and III IFNs …

[HTML][HTML] American-Asian-and African lineages of Zika virus induce differential pro-inflammatory and Interleukin 27-dependent antiviral responses in human monocytes

LJ Hernández-Sarmiento, JF Valdés-López… - Virus Research, 2023 - Elsevier
Zika virus (ZIKV) is an arbovirus that belongs to the Flaviviridae family and inflammatory
responses play a critical role in ZIKV pathogenesis. As a first-line defense, monocytes are …

[HTML][HTML] Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure

CBV Andrade, LVA Lopes, TM Ortiga-Carvalho… - Toxicology and Applied …, 2023 - Elsevier
Abstract P-glycoprotein (P-gp, encoded by the ABCB1 gene) and breast cancer resistance
protein (BCRP/ABCG2) are efflux multidrug resistance (MDR) transporters localized at the …

Mosquito-borne flaviviruses and type I interferon: catch me if you can!

J Zoladek, S Nisole - Frontiers in Microbiology, 2023 - frontiersin.org
Mosquito-borne flaviviruses include many viruses that are important human pathogens,
including Yellow fever virus, Dengue virus, Zika virus and West Nile virus. While these …

Immune recognition versus immune evasion systems in Zika virus infection

YT Chan, YY Cheok, HC Cheong, TF Tang, S Sulaiman… - Biomedicines, 2023 - mdpi.com
The reemergence of the Zika virus (ZIKV) infection in recent years has posed a serious
threat to global health. Despite being asymptomatic or mildly symptomatic in a majority of …