Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

Noncoding RNAs (ncRNAs) function with associated proteins to effect complex structural
and regulatory outcomes. To reveal the composition and dynamics of specific noncoding …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome
silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the …