The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
[HTML][HTML] Molecular mechanisms directing PRC2 recruitment and H3K27 methylation
A Laugesen, JW Højfeldt, K Helin - Molecular cell, 2019 - cell.com
The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation
MAJ Morgan, A Shilatifard - Nature genetics, 2020 - nature.com
Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …
processes including gene expression. Here, we outline historical and current thinking …
Context-specific Polycomb mechanisms in development
JJ Kim, RE Kingston - Nature Reviews Genetics, 2022 - nature.com
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
The interplay of histone modifications–writers that read
T Zhang, S Cooper, N Brockdorff - EMBO reports, 2015 - embopress.org
Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
[HTML][HTML] Systematic discovery of Xist RNA binding proteins
Noncoding RNAs (ncRNAs) function with associated proteins to effect complex structural
and regulatory outcomes. To reveal the composition and dynamics of specific noncoding …
and regulatory outcomes. To reveal the composition and dynamics of specific noncoding …
Principles of ubiquitin-dependent signaling
E Oh, D Akopian, M Rape - Annual review of cell and …, 2018 - annualreviews.org
Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …
[HTML][HTML] hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing
G Pintacuda, G Wei, C Roustan, BA Kirmizitas… - Molecular cell, 2017 - cell.com
The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome
silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the …
silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the …