Tunisia is one of the North African countries, geographically situated in a central position at
the crossroad between Africa and Europe. The demographic features of the Tunisian …

Colorectal cancer (CRC) is the third most common cause of cancer death in the world. The
incidence rate (ASR) and age distribution of this disease differ between most of African …

As one of the key tools on the precision medicine workbench, high-throughput genetic
testing has enormous promise for improving healthcare outcomes. Tunisia has made …

Background Familial adenomatous polyposis (known also as classical or severe FAP) is a
rare autosomal dominant colorectal cancer predisposition syndrome, characterized by the …

Germline mutations in the base excision repair gene MUTYH have been associated with
recessive inheritance of multiple colorectal adenomas. Screening of the MUTYH gene was …

Familial adenomatous polyposis (FAP) is caused by germline mutations in the tumor
suppressor gene APC. To date, nearly 2000 APC mutations have been described in FAP …

Lefevre JH, Colas C, Coulet F, Baert‐Desurmont S, Mongin C, Tiret E, Frebourg T, Soubrier
F, Parc Y. Frequent mutation in North African patients with MUTYH‐associated polyposis …

Introduction Familial adenomatous polyposis (FAP) is an autosomal dominant-inherited
disease caused by germline variants in the APC gene. It is characterized by the …

Familial adenomatous polyposis (FAP) is caused by germline mutations in the tumor
suppressor gene APC. To date, nearly 2000 APC mutations have been described in FAP …

Genetic disorders in the Arab world are a major cause of mortality, disability, and chronic
disease. Several of these disorders, being monogenic ones like hemoglobinopathies or due …