Dopaminergic signaling in the brain is primarily modulated by dopamine transporters
(DATs), which actively translocate extraneuronal dopamine back into dopaminergic …

Major depressive disorder (MDD) is etiologically complex and has a heterogeneous
presentation. This heterogeneity hinders the ability of molecular genetic research to reliably …

The neuromodulator dopamine affects learning and memory formation and their likely
physiological correlates, longterm depression and potentiation, in animals and humans. It …

The gene encoding the dopamine transporter (DAT) has been implicated in CNS disorders,
but the responsible polymorphisms remain uncertain. To search for regulatory …

The dopamine receptor D2 (encoded by DRD2) is implicated in susceptibility to mental
disorders and cocaine abuse, but mechanisms responsible for this relationship remain …

Using event-related functional magnetic resonance imaging (fMRI), we examined the effect
of video-game experience on the neural control of increasingly complex visuomotor tasks …

Personality traits related to emotion processing are, at least in part, heritable and genetically
determined. Dopamine D2 receptor signaling is involved in modulation of emotional …

Dopamine is synthesized in the nervous system where it acts as a neurotransmitter.
Dopamine is also synthesized in a number of peripheral organs as well as in several types …

Imaging genomics efforts worldwide are now working together to discover and replicate
many promising leads. By studying brain phenotypes closer to causative gene action, larger …

Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic
neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor …