Role of macrophages in pulmonary arterial hypertension

MQ Zhang, CC Wang, XB Pang, JZ Shi, HR Li… - Frontiers in …, 2023 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary vascular disease
characterized by progressive pulmonary artery pressure elevation, increased pulmonary …

The role of glutamine and glutaminase in pulmonary hypertension

S Wang, Y Yan, WJ Xu, SG Gong, XJ Zhong… - Frontiers in …, 2022 - frontiersin.org
Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome in which
pulmonary vascular resistance and pulmonary arterial pressure are increased due to …

Integrated transcriptomic and metabolomic analysis of cortical neurons reveals dysregulated lipid metabolism, enhanced glycolysis and activated HIF-1 signaling …

W Zhang, B Han, H Zhang, R Fu, Y Lu, G Zhang - Heliyon, 2023 - cell.com
The brain is the main oxygen-consuming organ and is vulnerable to ischemic shock or
insufficient blood perfusion. Brain hypoxia has a persistent and detrimental effect on resident …

Assessing and mitigating batch effects in large-scale omics studies

Y Yu, Y Mai, Y Zheng, L Shi - Genome Biology, 2024 - Springer
Batch effects in omics data are notoriously common technical variations unrelated to study
objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical …

Regulatory T cell-related gene indicators in pulmonary hypertension

Y Liu, JZ Shi, R Jiang, SF Liu, YY He… - Frontiers in …, 2022 - frontiersin.org
Objective: Regulatory T cells (Tregs) are critical immune modulators to maintain immune
homeostasis and limit pulmonary hypertension (PH). This study was aimed to identify Treg …

Animal models of pulmonary hypertension due to left heart disease

SF Liu, Y Yan - Animal Models and Experimental Medicine, 2022 - Wiley Online Library
Pulmonary hypertension due to left heart disease (PH‐LHD) is regarded as the most
prevalent form of pulmonary hypertension (PH). Indeed, PH is an independent risk factor …

MicroRNA‐210 mediates hypoxia‐induced pulmonary hypertension by targeting mitochondrial bioenergetics and mtROS flux

ASI Ahmed, AB Blood, L Zhang - Acta Physiologica, 2024 - Wiley Online Library
Aim Chronic hypoxia is a common cause of pulmonary hypertension (PH). We test the
hypothesis that microRNA‐210 (miR‐210) mediates hypoxia‐induced PH by targeting …

Metabolic reprogramming: A novel metabolic model for pulmonary hypertension

X Liu, L Zhang, W Zhang - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Pulmonary arterial hypertension, or PAH, is a condition that is characterized by pulmonary
artery pressures above 20 mmHg (at rest). In the treatment of PAH, the pulmonary vascular …

The role of prolactin/vasoinhibins in cardiovascular diseases

H Zhao, S Gong, Y Shi, C Luo, H Qiu… - Animal Models and …, 2023 - Wiley Online Library
Prolactin (PRL) is a polypeptide hormone that is mainly synthesized and secreted by the
lactotroph cells of the pituitary. There are two main isoforms of PRL: 23‐kDa PRL (named full …

[HTML][HTML] Hypoxia-Induced Mitochondrial ROS and Function in Pulmonary Arterial Endothelial Cells

H Wang, TY Song, J Reyes-García, YX Wang - Cells, 2024 - mdpi.com
Pulmonary artery endothelial cells (PAECs) are a major contributor to hypoxic pulmonary
hypertension (PH) due to the possible roles of reactive oxygen species (ROS). However, the …