NOD2 and inflammation: current insights

A Negroni, M Pierdomenico, S Cucchiara… - Journal of …, 2018 - Taylor & Francis
The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the
intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan …

MicroRNA biomarkers in IBD—differential diagnosis and prediction of colitis-associated cancer

JP James, LB Riis, M Malham, E Høgdall… - International journal of …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
These are chronic autoimmune diseases of unknown etiology affecting the gastrointestinal …

A guide to miRNAs in inflammation and innate immune responses

C Nejad, HJ Stunden, MP Gantier - The FEBS journal, 2018 - Wiley Online Library
The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …

Cow and human milk-derived exosomes ameliorate colitis in DSS murine model

S Reif, Y Elbaum-Shiff, N Koroukhov, I Shilo, M Musseri… - Nutrients, 2020 - mdpi.com
The aim of this study was to investigate the therapeutic effect of cow and human milk derived
exosomes (MDEs) on colitis. We used gavage administration of fluorescent labeled MDEs to …

miRNA effects on gut homeostasis: therapeutic implications for inflammatory bowel disease

S Dhuppar, G Murugaiyan - Trends in immunology, 2022 - cell.com
Inflammatory bowel disease (IBD) spans a range of chronic conditions affecting the
gastrointestinal (GI) tract, which are marked by intermittent flare-ups and remissions. IBD …

MicroRNA and gut microbiota: Tiny but mighty—Novel insights into their cross-talk in inflammatory bowel disease pathogenesis and therapeutics

M Casado-Bedmar, E Viennois - Journal of Crohn's and Colitis, 2022 - academic.oup.com
Abstract MicroRNAs [miRNAs], small non-coding RNAs, have recently been described as
crucial contributors to intestinal homeostasis. They can interact with the gut microbiota in a …

MicroRNAs regulate intestinal immunity and gut microbiota for gastrointestinal health: A comprehensive review

K Bi, X Zhang, W Chen, H Diao - Genes, 2020 - mdpi.com
MicroRNAs are small non-coding RNAs regulating gene expression at the post-
transcriptional level. The regulation of microRNA expression in the gut intestine is gradually …

IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair

LR Lopetuso, C De Salvo, L Pastorelli… - Proceedings of the …, 2018 - National Acad Sciences
Defective and/or delayed wound healing has been implicated in the pathogenesis of several
chronic inflammatory disorders, including inflammatory bowel disease (IBD). The resolution …

MiRNAs regulating insulin sensitivity are dysregulated in polycystic ovary syndrome (PCOS) ovaries and are associated with markers of inflammation and insulin …

F Cirillo, C Catellani, P Lazzeroni, C Sartori… - Frontiers in …, 2019 - frontiersin.org
Objective: MicroRNAs (miRNAs) are gene expression regulators. Altered miRNA levels are
associated with diabetes, insulin resistance, and inflammation. Insulin resistance and …

Multistage-responsive nanocomplexes attenuate ulcerative colitis by improving the accumulation and distribution of oral nucleic acid drugs in the colon

X Li, Y Yang, Z Wang, H Ju, X Fu, L Zou… - … Applied Materials & …, 2022 - ACS Publications
Oral gene therapy has emerged as a potential optimal treatment for ulcerative colitis (UC).
Nucleic acid drugs possessing versatility can not only inhibit inflammation but realize colon …