NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: Friend or foe?
X Chen, D Zhang, Y Li, W Wang, W Bei, J Guo - Pharmacological Research, 2021 - Elsevier
Type 2 diabetes and atherosclerosis have gradually garnered great attention as
inflammatory diseases. Previously, the fact that Interleukin-1β (IL-1β) accelerates the …
inflammatory diseases. Previously, the fact that Interleukin-1β (IL-1β) accelerates the …
The cellular function of SCAP in metabolic signaling
SH Lee, JH Lee, SS Im - Experimental & molecular medicine, 2020 - nature.com
Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a
key regulator of SREBP maturation. SCAP induces translocation of SREBP from the …
key regulator of SREBP maturation. SCAP induces translocation of SREBP from the …
The cytokine TNF promotes transcription factor SREBP activity and binding to inflammatory genes to activate macrophages and limit tissue repair
Cytokine tumor necrosis factor (TNF)-mediated macrophage polarization is important for
inflammatory disease pathogenesis, but the mechanisms regulating polarization are not …
inflammatory disease pathogenesis, but the mechanisms regulating polarization are not …
[HTML][HTML] Macrophage SCAP contributes to metaflammation and lean NAFLD by activating STING–NF-κB signaling pathway
X Huang, Y Yao, X Hou, L Wei, Y Rao, Y Su… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Sterol regulatory element binding protein cleavage-activating protein
(SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic …
(SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic …
The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
X Fei, J Huang, F Li, Y Wang, Z Shao, L Dong, Y Wu… - Cell Reports, 2023 - cell.com
The nuclear factor κB (NF-κB) pathway plays essential roles in innate and adaptive
immunity, but little is known how NF-κB signaling is compartmentalized and spatiotemporally …
immunity, but little is known how NF-κB signaling is compartmentalized and spatiotemporally …
[HTML][HTML] Hyperactivation of SREBP induces Pannexin-1-dependent lytic cell death
Y Xiong, J Luo, ZY Hong, WZ Zhu, A Hu… - Journal of Lipid Research, 2024 - Elsevier
Sterol-regulatory element binding proteins (SREBPs) are a conserved transcription factor
family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is …
family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is …
Inflammation induced by lipopolysaccharide and palmitic acid increases cholesterol accumulation via enhancing myeloid differentiation factor 88 expression in HepG2 …
J Chen, Y Liu, H Luo, G Chen, Z Zheng, T Wang, X Hu… - Pharmaceuticals, 2022 - mdpi.com
Recently, multiple studies have shown that chronic inflammation disturbs cholesterol
homeostasis and promotes its accumulation in the liver. The underlying molecular …
homeostasis and promotes its accumulation in the liver. The underlying molecular …
Research progress of SREBP and its role in the pathogenesis of autoimmune rheumatic diseases
X Xu, W Jin, R Chang, X Ding - Frontiers in Immunology, 2024 - frontiersin.org
Autoimmune rheumatic diseases comprise a group of immune-related disorders
characterized by non-organ-specific inflammation. These diseases include systemic lupus …
characterized by non-organ-specific inflammation. These diseases include systemic lupus …
SCAP mediated GDF15-induced invasion and EMT of esophageal cancer
G Dong, X Huang, S Jiang, L Ni, L Ma, C Zhu… - Frontiers in …, 2020 - frontiersin.org
Background: GDF15 is a potential biomarker for patients with esophageal cancer (EC).
However, the mechanistic role of GDF15 in the invasion and metastasis of EC remains …
However, the mechanistic role of GDF15 in the invasion and metastasis of EC remains …
甾醇调节元件结合蛋白在创面修复中的作用机制与应用途径
朱博恒， 彭颖， 汪虹 - 中国组织工程研究, 2022 - cjter.com
甾醇调节元件结合蛋白在创面修复中的作用机制与应用途径 Page 1 Chinese Journal of Tissue
Engineering Research|Vol 26|No.29|October 2022|4729 中国组织工程研究 Chinese Journal of …
Engineering Research|Vol 26|No.29|October 2022|4729 中国组织工程研究 Chinese Journal of …