Morbidity and mortality from ischaemic heart disease (IHD) and heart failure (HF) remain
significant in Europe and are increasing worldwide. Patients with IHD or HF might benefit …

In recent years, conditioned medium (CM) obtained from the culture of mesenchymal
stromal/stem cells (MSCs) has been shown to effectively promote tissue repair and modulate …

Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated
with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing …

Mesenchymal stem cell spheroids have been encapsulated in hydrogels for various
applications because spheroids demonstrate higher cell activity than individual cells in …

Mesenchymal stem cells (MSCs) are considered as primary candidates for cell-based
therapies due to their multiple effects in regenerative medicine. Pre-conditioning of MSCs …

The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process,
which plays a critical role in embryonic development, wound healing, tissue regeneration …

Multicellular spheroids generated through cellular self-assembly provide cytoarchitectural
complexities of native tissue including three-dimensionality, extensive cell-cell contacts, and …

The increased knowledge in cell signals and stem cell differentiation, together with the
development of new technologies, such as 3D bioprinting, has made the generation of …

Cardiac stromal cells have been long underestimated in their functions in homeostasis and
repair. Recent evidence has changed this perspective in that many more players and facets …

The 'cardiosphere'is a 3D cluster of cardiac progenitor cells recapitulating a stem cell niche-
like microenvironment with a potential for disease and regeneration modelling of the failing …