Base excision repair is the system used from bacteria to man to remove the tens of
thousands of endogenous DNA damages produced daily in each human cell. Base excision …

XPC polymorphisms may alter DNA repair capacity, thus leading to genetic instability and
carcinogenesis. Numerous studies have investigated the associations of XPC Lys939Gln …

Lead is still widely used in many industrial processes and is very persistent in the
environment. Although toxic effects caused by occupational exposure to lead have been …

The base excision repair (BER) pathway involves gap filling by DNA polymerase (pol) β and
subsequent nick sealing by ligase IIIα. X-ray cross-complementing protein 1 (XRCC1), a …

Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision
Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the …

Genome-wide association studies (GWASs) have identified low-penetrance common
variants (ie, single nucleotide polymorphisms, SNPs) associated with breast cancer …

Abstract Sirtuin 2 (SIRT2) regulates the maintenance of genome integrity by targeting
pathways of DNA damage response and homologous recombination repair. However …

Breast cancer (BC) is the most common cancer among women worldwide. The aetiology
and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and …

Altered DNA repair capacity can result in increased susceptibility to cancer. The base
excision repair (BER) pathway effectively removes DNA damage caused by ionizing …

Background/Aim: Xeroderma pigmentosum complementation group C (XPC) is reported to
play important roles in DNA integrity and genomic instability, however, the contribution of …