The meaning of the word mitochondrion (from the Greek mitos, meaning thread, and
chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been …

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting
network. The molecular machinery that mediates this organelle fission and fusion is …

Mitochondria, the membrane-bound cell organelles that supply most of the energy needed
for cell function, are highly regulated, dynamic organelles bearing the ability to alter both …

Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing
processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial …

Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion.
Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by …

During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA
interference, we manipulated the expression levels of the proteins hFis1, Drp1, and Opa1 …

Mitochondria are derived from eubacteria; however, in most eukaryotes, novel mechanisms
for the propagation of this organelle and its genome have evolved. This review focuses on …

Mitochondria fuse and divide continuously within cells to form a dynamic network. One of the
steps in apoptosis is the fragmentation of mitochondria, and recent evidence indicates that …

Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the
behavior of mitochondria inside eukaryotic cells has changed dramatically, and the …