Cancer has been a serious public health problem. Berberine is a famous natural compound
from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory …

Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. The
limitations of current chemotherapeutic drugs in CRC include their toxicity, side effects, and …

Chemotherapy-induced peripheral neuropathy (CIPN) often develops in patients with cancer
treated with commonly used anti-cancer drugs. The symptoms of CIPN can occur acutely …

Gemcitabine (Gem)-based chemotherapy is one of the first-line treatments for pancreatic
ductal adenocarcinoma (PDAC). However, its clinical effect is limited due to development of …

Objective This study aimed to investigate the effect of proanthocyanidin (PA) on
osteogenesis mediated by periodontal ligament stem cells (PDLSCs) and endogenous …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy, primarily due to the
intrinsic development of chemoresistance. The most apparent histopathological feature …

Introduction: Berberine is a natural isoquinoline alkaloid with anti-cancer properties.
Nevertheless, the underlying mechanism of its action in human colorectal cancer (CRC) has …

Lenvatinib is a multi-kinase inhibitor approved as a first-line treatment for patients with
unresectable advanced hepatocellular carcinoma (HCC). However, its response rate is …

Background Berberine is a natural isoquinoline alkaloid that has been shown to have
antitumor properties in a growing number of studies. However, its role in renal cell …

A series of novel 9-N-substituted-13-alkylberberine derivatives from Chinese medicine were
designed and synthesized with improved anti-hepatocellular carcinoma (HCC) activities …