From the 1940s to the 1960s, the discovery of antibiotics held substantial promise for the
treatment of bacterial infection, and it was also widely used in food, agriculture, and other …

The rapid increase in drug-resistant infections has presented a serious challenge to
antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” …

Antimicrobial peptides (AMPs) are showing increasing promise as potential candidate
antibacterial drugs in the face of the rapidly emerging bacterial resistance to conventional …

Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

The increasing prevalence of antibiotic-resistant bacterial infections, coupled with the
decline in the number of new antibiotic drug approvals, has created a therapeutic gap that …

Hundreds of peptide antibiotics have been described in the past half-century (20, 28, 35).
These fall into two classes, nonribosomally synthesized peptides, such as the gramicidins …

Gene‐encoded antimicrobial peptides are an important component of host defense in
animals ranging from insects to mammals. They do not target specific molecular receptors …

Antibacterial, membrane-lytic peptides belong to the innate immune system and host
defense mechanism of a multitude of animals and plants. The largest group of peptide …

The concept of antimicrobial peptides (AMPs) as potent pharmaceuticals is firmly
established in the literature, and most research articles on this topic conclude by stating that …

During the past year, additional insights into systems that regulate antimicrobial peptide
production in Drosophila were reported. Granulysin, a peptide stored in the cytoplasmic …