[HTML][HTML] Drosophila as a model to explore secondary injury cascades after traumatic brain injury
LM Buhlman, G Krishna, TB Jones… - Biomedicine & …, 2021 - Elsevier
Drosophilae are emerging as a valuable model to study traumatic brain injury (TBI)-induced
secondary injury cascades that drive persisting neuroinflammation and neurodegenerative …
secondary injury cascades that drive persisting neuroinflammation and neurodegenerative …
Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma
Repetitive physical insults to the head, including those that elicit mild traumatic brain injury
(mTBI), are a known risk factor for a variety of neurodegenerative conditions including …
(mTBI), are a known risk factor for a variety of neurodegenerative conditions including …
Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila
B van Alphen, S Stewart, M Iwanaszko, F Xu, K Li… - PLoS …, 2022 - journals.plos.org
In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that
contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo …
contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo …
Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila
Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated
development of neurodegenerative diseases. There are currently no therapeutics to address …
development of neurodegenerative diseases. There are currently no therapeutics to address …
Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator
Drosophila models have been instrumental in providing insights into molecular mechanisms
of neurodegeneration, with wide application to human disease. The brain degeneration …
of neurodegeneration, with wide application to human disease. The brain degeneration …
Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
Mild head trauma, including concussion, can lead to chronic brain dysfunction and
degeneration but the underlying mechanisms remain poorly understood. Here, we …
degeneration but the underlying mechanisms remain poorly understood. Here, we …
Adverse impact of female reproductive signaling on age-dependent neurodegeneration after mild head trauma in Drosophila
Environmental insults, including mild head trauma, significantly increase the risk of
neurodegeneration. However, it remains challenging to establish a causative connection …
neurodegeneration. However, it remains challenging to establish a causative connection …
The past and present of Drosophila models of traumatic brain injury
P Aggarwal, D Thapliyal, S Sarkar - Journal of Neuroscience Methods, 2022 - Elsevier
Traumatic brain injuries are highly recognized as one of the leading causes of mortality and
morbidity worldwide. A chronic and debilitating condition by nature, TBI is reportedly …
morbidity worldwide. A chronic and debilitating condition by nature, TBI is reportedly …
The utilization of small non‐mammals in traumatic brain injury research: A systematic review
Traumatic brain injury (TBI) is the leading cause of death and disability worldwide and has
complicated underlying pathophysiology. Numerous TBI animal models have been …
complicated underlying pathophysiology. Numerous TBI animal models have been …
Recent insights from non-mammalian models of brain injuries: an emerging literature
NJ Katchur, DA Notterman - Frontiers in Neurology, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a major global health concern and is increasingly recognized
as a risk factor for neurodegenerative diseases including Alzheimer's disease (AD) and …
as a risk factor for neurodegenerative diseases including Alzheimer's disease (AD) and …