[HTML][HTML] Drosophila as a model to explore secondary injury cascades after traumatic brain injury

LM Buhlman, G Krishna, TB Jones… - Biomedicine & …, 2021 - Elsevier
Drosophilae are emerging as a valuable model to study traumatic brain injury (TBI)-induced
secondary injury cascades that drive persisting neuroinflammation and neurodegenerative …

Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma

C Ye, JA Behnke, KR Hardin, JQ Zheng - Frontiers in Neuroscience, 2023 - frontiersin.org
Repetitive physical insults to the head, including those that elicit mild traumatic brain injury
(mTBI), are a known risk factor for a variety of neurodegenerative conditions including …

Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila

B van Alphen, S Stewart, M Iwanaszko, F Xu, K Li… - PLoS …, 2022 - journals.plos.org
In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that
contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo …

Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila

J Saikumar, CN Byrns, M Hemphill… - Proceedings of the …, 2020 - National Acad Sciences
Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated
development of neurodegenerative diseases. There are currently no therapeutics to address …

Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator

J Saikumar, J Kim, CN Byrns, M Hemphill… - Nature protocols, 2021 - nature.com
Drosophila models have been instrumental in providing insights into molecular mechanisms
of neurodegeneration, with wide application to human disease. The brain degeneration …

Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model

JA Behnke, C Ye, A Setty, KH Moberg, JQ Zheng - Scientific Reports, 2021 - nature.com
Mild head trauma, including concussion, can lead to chronic brain dysfunction and
degeneration but the underlying mechanisms remain poorly understood. Here, we …

Adverse impact of female reproductive signaling on age-dependent neurodegeneration after mild head trauma in Drosophila

C Ye, R Ho, KH Moberg, JQ Zheng - Elife, 2024 - elifesciences.org
Environmental insults, including mild head trauma, significantly increase the risk of
neurodegeneration. However, it remains challenging to establish a causative connection …

The past and present of Drosophila models of traumatic brain injury

P Aggarwal, D Thapliyal, S Sarkar - Journal of Neuroscience Methods, 2022 - Elsevier
Traumatic brain injuries are highly recognized as one of the leading causes of mortality and
morbidity worldwide. A chronic and debilitating condition by nature, TBI is reportedly …

The utilization of small non‐mammals in traumatic brain injury research: A systematic review

NA Zulazmi, A Arulsamy, I Ali… - CNS Neuroscience …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) is the leading cause of death and disability worldwide and has
complicated underlying pathophysiology. Numerous TBI animal models have been …

Recent insights from non-mammalian models of brain injuries: an emerging literature

NJ Katchur, DA Notterman - Frontiers in Neurology, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a major global health concern and is increasingly recognized
as a risk factor for neurodegenerative diseases including Alzheimer's disease (AD) and …