While deforestation rates decline globally they are rising in the Western Amazon. Artisanal-
scale gold mining (ASGM) is a large cause of this deforestation and brings with it extensive …

Isocitrate dehydrogenases (IDHs) are enzymes that catalyze the oxidative decarboxylation
of isocitrate, producing α-ketoglutarate (αKG) and CO2. The discovery of IDH1 and IDH2 …

Whether glucose is predominantly metabolized via oxidative phosphorylation or glycolysis
differs between quiescent versus proliferating cells, including tumor cells. However, how …

Kidney donation after circulatory death (DCD) is a less than ideal option to meet organ
shortages. Hypothermic machine perfusion (HMP) with Belzer solution (BS) improves the …

Significance: The long-term hematopoietic stem cell (LT-HSC) demonstrates characteristics
of self-renewal and the ability to manage expansion of the hematopoietic compartment while …

Cardiac hypertrophy, a risk factor for heart failure, is associated with enhanced oxidative
stress in the mitochondria, resulting from high levels of reactive oxygen species (ROS). The …

Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-
producing enzyme which is essential for maintaining the mitochondrial redox balance in …

Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) is a major producer of
mitochondrial NADPH, required for glutathione (GSH)-associated mitochondrial antioxidant …

Abstract Isocitrate dehydrogenase 2 (IDH2) is an NADP+-dependent enzyme that catalyzes
the oxidative decarboxylation of isocitrate to α-ketoglutarate in the mitochondrial matrix, and …

Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative
decarboxylation of isocitrate to α-ketoglutarate, synthesizing NADPH, which is essential for …