Protozoan Kinetoplastida, including the pathogenic trypanosomatids of the genera
Trypanosoma and Leishmania, compartmentalize several important metabolic systems in …

Glycolysis is perceived as a promising target for new drugs against parasitic trypanosomatid
protozoa because this pathway plays an essential role in their ATP supply. Trypanosomatid …

An introduction to the mathematical concepts and techniques needed for the construction
and analysis of models in molecular systems biology. Systems techniques are integral to …

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism
of glucose to lactate. It remains unknown what quantitative changes to the activity of …

Metabolic control analysis (MCA) provides a quantitative description of substrate flux in
response to changes in system parameters of complex enzyme systems. Medical …

The traditional experimental approaches used for changing the flux or the concentration of a
particular metabolite of a metabolic pathway have been mostly based on the inhibition or …

Kinetoplastida are protozoan organisms that probably diverged early in evolution from other
eukaryotes. They are characterized by a number of unique features with respect to their …

Oncogenesis results from changes in kinetics or in abundance of proteins in signal
transduction networks. Recently, it was shown that control of signalling cannot reside in a …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

General and simple principles are identified that govern signal transduction. The effects of
kinase and phosphatase inhibition on a MAP kinase pathway are first examined in silico …