The fusion oncogene, promyelocytic leukaemia (PML)–retinoic acid receptor-α (RARA),
initiates acute promyelocytic leukaemia (APL) through both a block to differentiation and …

PU. 1 directs the hematopoietic stem cell to the lymphoid-myeloid progenitor (LMP) and
interacts with GATA-binding protein 1 to inhibit commitment to the megakaryocyte-erythroid …

Langerhans cells (LCs) in epithelia and interstitial dendritic cells (intDCs) in adjacent
connective tissues represent two closely related myeloid-derived DC subsets that exert …

Transforming growth factor-β1 (TGF-β1) is a fundamental regulator of immune cell
development and function. In this study, we investigated the effects of TGF-β1 on the …

As the result of intense clinical and basic research, acute promyelocytic leukemia (APL) has
progressively evolved from a deadly to a curable disease. Historically, efforts aimed at …

Neutrophils are often considered terminally differentiated and poised for bacterial killing. In
chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive …

Human Langerhans cell (LC) precursors populate the epidermis early during prenatal
development and thereafter undergo massive proliferation. The prototypic antiproliferative …

The transcription factor aryl hydrocarbon receptor (AhR) represents a promising therapeutic
target in allergy and autoimmunity. AhR signaling induced by the newly described ligand …

The identification of novel drug targets for the treatment of ischemic stroke is currently an
urgent challenge. Recent experimental findings have highlighted the neuroprotective …

Although PML-enforced RARA homodimerization allows PML/RARA to bind DNA
independently of its coreceptor RXR, the latter was identified within the PML/RARA complex …