The architectures of iterative type I PKS and FAS
DA Herbst, CA Townsend, T Maier - Natural product reports, 2018 - pubs.rsc.org
Covering: up to mid of 2018 Type I fatty acid synthases (FASs) are giant multienzymes
catalyzing all steps of the biosynthesis of fatty acids from acetyl-and malonyl-CoA by iterative …
catalyzing all steps of the biosynthesis of fatty acids from acetyl-and malonyl-CoA by iterative …
Biosynthesis of cyclopropane in natural products
Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …
pharmaceutical chemistry, and chemical biology because of its unique structural and …
Engineering strategies for rational polyketide synthase design
M Klaus, M Grininger - Natural product reports, 2018 - pubs.rsc.org
Covering: mid 1990s to 2018 Over the last two decades, diverse approaches have been
explored to generate new polyketides by engineering polyketide synthases (PKSs) …
explored to generate new polyketides by engineering polyketide synthases (PKSs) …
Animal fatty acid synthase: a chemical nanofactory
Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …
across species. These molecules play a role in energy storage, cell membrane architecture …
The hidden enzymology of bacterial natural product biosynthesis
TA Scott, J Piel - Nature Reviews Chemistry, 2019 - nature.com
Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …
them with a remarkable range of biological activities that are of significant value to modern …
The uncommon enzymology of cis-acyltransferase assembly lines
AT Keatinge-Clay - Chemical reviews, 2017 - ACS Publications
The enzymology of 135 assembly lines containing primarily cis-acyltransferase modules is
comprehensively analyzed, with greater attention paid to less common phenomena. Diverse …
comprehensively analyzed, with greater attention paid to less common phenomena. Diverse …
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases
Polyketide synthases (PKSs) are biosynthetic factories that produce natural products with
important biological and pharmacological activities,,. Their exceptional product diversity is …
important biological and pharmacological activities,,. Their exceptional product diversity is …
Polyketide β-branching: diversity, mechanism and selectivity
PD Walker, ANM Weir, CL Willis, MP Crump - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2008 to August 2020 Polyketides are a family of natural products constructed from
simple building blocks to generate a diverse range of often complex chemical structures with …
simple building blocks to generate a diverse range of often complex chemical structures with …
Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase
MA Skiba, AP Sikkema, WD Fiers… - ACS chemical …, 2016 - ACS Publications
Polyketide metabolites produced by modular type I polyketide synthases (PKS) acquire their
chemical diversity through the variety of catalytic domains within modules of the pathway …
chemical diversity through the variety of catalytic domains within modules of the pathway …
Protein–protein interactions in “cis-AT” polyketide synthases
GJ Dodge, FP Maloney, JL Smith - Natural product reports, 2018 - pubs.rsc.org
Covering: up to the end of 2018 Polyketides are a valuable source of bioactive and clinically
important molecules. The biosynthesis of these chemically complex molecules has led to the …
important molecules. The biosynthesis of these chemically complex molecules has led to the …