Covering: up to mid of 2018 Type I fatty acid synthases (FASs) are giant multienzymes
catalyzing all steps of the biosynthesis of fatty acids from acetyl-and malonyl-CoA by iterative …

Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …

Covering: mid 1990s to 2018 Over the last two decades, diverse approaches have been
explored to generate new polyketides by engineering polyketide synthases (PKSs) …

Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …

Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …

The enzymology of 135 assembly lines containing primarily cis-acyltransferase modules is
comprehensively analyzed, with greater attention paid to less common phenomena. Diverse …

Polyketide synthases (PKSs) are biosynthetic factories that produce natural products with
important biological and pharmacological activities,,. Their exceptional product diversity is …

Covering: 2008 to August 2020 Polyketides are a family of natural products constructed from
simple building blocks to generate a diverse range of often complex chemical structures with …

Polyketide metabolites produced by modular type I polyketide synthases (PKS) acquire their
chemical diversity through the variety of catalytic domains within modules of the pathway …

Covering: up to the end of 2018 Polyketides are a valuable source of bioactive and clinically
important molecules. The biosynthesis of these chemically complex molecules has led to the …