Metabotropic glutamate receptors: from the workbench to the bedside
Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …
Glutamatergic substrates of drug addiction and alcoholism
JT Gass, MF Olive - Biochemical pharmacology, 2008 - Elsevier
The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …
the excitatory amino acid glutamate plays an important role in drug addiction and …
Endogenous opiates and behavior: 2005
RJ Bodnar, GE Klein - Peptides, 2006 - Elsevier
This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …
the endogenous opioid system, now spanning over a quarter-century of research. It …
Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release
H Homayoun, MR Stefani, BW Adams… - …, 2004 - nature.com
Pharmacological manipulation of N-methyl-D-aspartate (NMDA) receptors may be critical for
the treatment of many neurological and psychiatric disorders. Metabotropic glutamate …
the treatment of many neurological and psychiatric disorders. Metabotropic glutamate …
mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior
P Bäckström, D Bachteler, S Koch, P Hyytiä… - …, 2004 - nature.com
The glutamatergic system plays an important role in mediating neurobehavioral effects of
ethanol. Metabotropic glutamate receptors subtype 5 (mGluR5) are modulators of …
ethanol. Metabotropic glutamate receptors subtype 5 (mGluR5) are modulators of …
Pharmacodynamics of memantine: an update
CG Parsons, G Rammes… - Current …, 2008 - ingentaconnect.com
Memantine received marketing authorization from the European Agency for the Evaluation
of Medicinal Products (EMEA) for the treatment of moderately severe to severe Alzheimer's …
of Medicinal Products (EMEA) for the treatment of moderately severe to severe Alzheimer's …
The glutamatergic system as a target for neuropathic pain relief
M Osikowicz, J Mika, B Przewlocka - Experimental physiology, 2013 - Wiley Online Library
New findings• What is the topic of this review? This paper presents a review of the literature
of glutamate receptors and transporters in neuropathic pain and the role of glia in these …
of glutamate receptors and transporters in neuropathic pain and the role of glia in these …
Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests
Drugs that act to reduce glutamatergic neurotransmission such as NMDA receptor
antagonists exert antidepressant-like effects in a variety of experimental paradigms, but their …
antagonists exert antidepressant-like effects in a variety of experimental paradigms, but their …
Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens
Dysregulation of histone modifying enzymes has been associated with numerous psychiatric
disorders. Alterations in G9a (Ehmt2), a histone methyltransferase that catalyzes the …
disorders. Alterations in G9a (Ehmt2), a histone methyltransferase that catalyzes the …
Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP
PM Lea IV, AI Faden - CNS drug reviews, 2006 - Wiley Online Library
Glutamate regulates the function of central nervous system (CNS), in part, through the cAMP
and/or IP3/DAG second messenger‐associated metabotropic glutamate receptors (mGluRs) …
and/or IP3/DAG second messenger‐associated metabotropic glutamate receptors (mGluRs) …