Serine metabolism in health and disease and as a conditionally essential amino acid
M Holeček - Nutrients, 2022 - mdpi.com
L-serine plays an essential role in a broad range of cellular functions including protein
synthesis, neurotransmission, and folate and methionine cycles and synthesis of …
synthesis, neurotransmission, and folate and methionine cycles and synthesis of …
Cognitive impairment associated with schizophrenia: from pathophysiology to treatment
DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
The schizophrenia syndrome, circa 2024: What we know and how that informs its nature
R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?
J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …
conferring risk to the disorder. This progress offers an important route toward defining the …
d-Amino acids: new clinical pathways for brain diseases
IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …
molecules in many organs, including the brain and endocrine systems. There has been …
Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory …
Question This umbrella review and guidelines aimed to provide evidence to support the
rational choice of selected adjunctive therapies for schizophrenia. Study selection and …
rational choice of selected adjunctive therapies for schizophrenia. Study selection and …
Rational and translational implications of D-amino acids for treatment-resistant schizophrenia: from neurobiology to the clinics
A de Bartolomeis, L Vellucci, MC Austin, G De Simone… - Biomolecules, 2022 - mdpi.com
Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …
Novel compounds in the treatment of schizophrenia—a selective review
EM Tsapakis, K Diakaki, A Miliaras, KN Fountoulakis - Brain Sciences, 2023 - mdpi.com
Schizophrenia is a chronic neuropsychiatric syndrome that significantly impacts daily
function and quality of life. All of the available guidelines suggest a combined treatment …
function and quality of life. All of the available guidelines suggest a combined treatment …
A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine
K Fukuyama, E Motomura, M Okada - Biomolecules, 2023 - mdpi.com
Clozapine is listed as one of the most effective antipsychotics and has been approved for
treating treatment-resistant schizophrenia (TRS); however, several type A and B adverse …
treating treatment-resistant schizophrenia (TRS); however, several type A and B adverse …
Canonical and non-canonical antipsychotics' dopamine-related mechanisms of present and next generation molecules: a systematic review on translational highlights …
A de Bartolomeis, M Ciccarelli, G De Simone… - International Journal of …, 2023 - mdpi.com
Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …