[HTML][HTML] Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management

MCZ Zotin, L Sveikata, A Viswanathan… - Current opinion in …, 2021 - journals.lww.com
SVD is the leading cause of VCI and is associated with substantial morbidity. Tackling
cardiovascular risk factors is currently the most effective approach to prevent cognitive …

Peak width of skeletonized mean diffusivity: a neuroimaging marker for white matter injury

MC Zanon Zotin, P Yilmaz, L Sveikata, D Schoemaker… - Radiology, 2023 - pubs.rsna.org
A leading cause of white matter (WM) injury in older individuals is cerebral small vessel
disease (SVD). Cerebral SVD is the most prevalent vascular contributor to cognitive …

[HTML][HTML] Functional connectivity changes in cerebral small vessel disease-a systematic review of the resting-state MRI literature

M Schulz, C Malherbe, B Cheng, G Thomalla… - BMC medicine, 2021 - Springer
Background Cerebral small vessel disease (CSVD) is a common neurological disease
present in the ageing population that is associated with an increased risk of dementia and …

[HTML][HTML] Fixel based analysis of white matter alterations in early stage cerebral small vessel disease

M Petersen, BM Frey, C Mayer, S Kühn, J Gallinat… - Scientific reports, 2022 - nature.com
Cerebral small vessel disease (CSVD) is a common cause of morbidity and cognitive
decline in the elderly population. However, characterizing the disease pathophysiology and …

Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study

C Mayer, C Walther, K Borof, FL Nägele… - Journal of Clinical …, 2023 - Wiley Online Library
Aim The aim of the PAROBRAIN study was to examine the association of periodontal health
with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the …

Microvascular Dysfunction and Whole‐Brain White Matter Connectivity: The Maastricht Study

M Beran, ACE van Gennip… - Journal of the …, 2024 - Am Heart Assoc
Background Microvascular dysfunction is involved in the development of various cerebral
disorders. It may contribute to these disorders by disrupting white matter tracts and altering …

Long-range connections damage in white matter hyperintensities affects information processing speed

T Lu, Z Wang, Y Zhu, M Wang, CQ Lu… - Brain …, 2024 - academic.oup.com
White matter hyperintensities, one of the major markers of cerebral small vessel disease,
disrupt the integrity of neuronal networks and ultimately contribute to cognitive dysfunction …

Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: a coronary artery risk development in young adults …

WSH Kim, NJ Luciw, S Atwi, Z Shirzadi… - Human Brain …, 2022 - Wiley Online Library
White matter hyperintensities (WMHs) are emblematic of cerebral small vessel disease, yet
effects on the brain have not been well characterized at midlife. Here, we investigated …

Small vessel disease and cognitive reserve oppositely modulate global network redundancy and cognitive function: A study in middle‐to‐old aged community …

L Cui, H Hong, S Wang, Q Zeng… - Human Brain …, 2024 - Wiley Online Library
Cerebral small vessel disease (SVD) can disrupt the global brain network and lead to
cognitive impairment. Conversely, cognitive reserve (CR) can improve one's cognitive ability …

[HTML][HTML] Characterizing upper extremity fine motor function in the presence of white matter hyperintensities: A 7 T MRI cross-sectional study in older adults

R Iandolo, E Avci, G Bommarito, I Sandvig… - NeuroImage: Clinical, 2024 - Elsevier
Background White matter hyperintensities (WMH) are a prevalent radiographic finding in the
aging brain studies. Research on WMH association with motor impairment is mostly focused …