The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …

Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease,
manifested by syncope or sudden death in children or young adults under stress conditions …

Diastolic calcium (Ca) leak via cardiac ryanodine receptors (RyR2) can cause arrhythmias
and heart failure (HF). Ca/calmodulin (CaM)-dependent kinase II (CaMKII) is upregulated …

Dantrolene is an intra-cellularly acting skeletal muscle relaxant used for the treatment of the
rare genetic disorder, malignant hyperthermia (MH). In most cases, MH susceptibility is …

Cardiac muscle contraction requires sarcoplasmic reticulum (SR) Ca2+ release mediated by
the quaternary complex comprising the ryanodine receptor 2 (RyR2), calsequestrin 2 …

The N-terminal region (NTR) of ryanodine receptor (RyR) channels is critical for the
regulation of Ca 2+ release during excitation–contraction (EC) coupling in muscle. The NTR …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, lethal
ventricular arrhythmia triggered by catecholamines. Mutations in genes that encode cardiac …

Aims The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca2+ release to
trigger cardiomyocyte contraction, participates in development of acquired and inherited …

The ryanodine receptor (RyR) is a homotetrameric channel mediating sarcoplasmic
reticulum Ca2+ release required for skeletal and cardiac muscle contraction. Mutations in …