Intracellular vesicular transport along cytoskeletal filaments ensures targeted cargo delivery.
Such transport is rarely unidirectional but rather bidirectional, with frequent directional …

Intracellular mature viruses (IMVs) are the first and most abundant infectious form of vaccinia
virus to assemble during its replication cycle. IMVs can undergo microtubule-based motility …

Kinesin-1 ensembles maneuver vesicular cargoes through the three-dimensional (3D)
intracellular microtubule (MT) network. To define how such cargoes navigate MT …

Diatoms are unicellular microalgae with a rigid cell wall, able to glide on surfaces by
releasing nanopolymeric fibers through central slits known as raphes. Here we consider the …

The stepping dynamics of cytoskeletal motor proteins determines the dynamics of cargo
transport. In its native cellular environment, a molecular motor is subject to forces from …

SUMMARY Microtubule (MT)-associated proteins (MAPs) regulate intracellular transport by
selectively recruiting or excluding kinesin and dynein motors from MTs. We used single …

Each cargo in a cell employs a unique set of motor proteins for its transport. Often multiple
types of kinesins are bound to the same cargo. It is puzzling why several types of motors are …

The microtubule (MT) cytoskeleton underlies processes such as intracellular transport and
cell division. Immunolabeling for post-translational modifications of tubulin has revealed the …

Molecular motors often work in teams to move a cellular cargo. Yet measuring the forces
exerted by each motor is challenging. Using a sensor made with denatured ssDNA and multi …

Molecular motors are fascinating proteins that use the energy of ATP hydrolysis to drive
vesicles and organelles along cytoskeleton filaments toward their final destination within the …