Measuring allostatic load: Approaches and limitations to algorithm creation
JT Carbone, J Clift, N Alexander - Journal of Psychosomatic Research, 2022 - Elsevier
Objective Allostatic load literature has proliferated over the past three decades, and a
growing body of research demonstrates that higher levels of allostatic load are associated …
growing body of research demonstrates that higher levels of allostatic load are associated …
[HTML][HTML] AI and machine learning in resuscitation: ongoing research, new concepts, and key challenges
Aim Artificial intelligence (AI) and machine learning (ML) are important areas of computer
science that have recently attracted attention for their application to medicine. However, as …
science that have recently attracted attention for their application to medicine. However, as …
Latent class analysis reveals COVID-19–related acute respiratory distress syndrome subgroups with differential responses to corticosteroids
P Sinha, D Furfaro, MJ Cummings… - American journal of …, 2021 - atsjournals.org
Rationale: Two distinct subphenotypes have been identified in acute respiratory distress
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
P Sinha, VE Kerchberger, A Willmore… - The Lancet …, 2023 - thelancet.com
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …
Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts
Background Patients with COVID-19-related acute respiratory distress syndrome (ARDS)
have been postulated to present with distinct respiratory subphenotypes. However, most …
have been postulated to present with distinct respiratory subphenotypes. However, most …
Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis
Background Previous latent class analysis of adults with acute respiratory distress syndrome
(ARDS) identified two phenotypes, distinguished by the degree of inflammation. We aimed …
(ARDS) identified two phenotypes, distinguished by the degree of inflammation. We aimed …
Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study
P Sinha, KL Delucchi, Y Chen, H Zhuo, J Abbott… - Thorax, 2022 - thorax.bmj.com
Rationale Using latent class analysis (LCA), two subphenotypes of acute respiratory distress
syndrome (ARDS) have consistently been identified in five randomised controlled trials …
syndrome (ARDS) have consistently been identified in five randomised controlled trials …
The prevalence of MAFLD and its association with atrial fibrillation in a nationwide health check-up population in China
F Lei, JJ Qin, X Song, YM Liu, MM Chen… - Frontiers in …, 2022 - frontiersin.org
Background and aims The epidemiological characteristics of MAFLD and its relationship
with atrial fibrillation (AF) are limited in China. Therefore, we explored the epidemiological …
with atrial fibrillation (AF) are limited in China. Therefore, we explored the epidemiological …
Associations of symptom clusters and health outcomes in adult survivors of childhood cancer: A report from the St Jude lifetime cohort study
PURPOSE To identify symptom clusters among adult survivors of childhood cancers and test
associations with health-related quality of life (HRQOL) and physical and neurocognitive …
associations with health-related quality of life (HRQOL) and physical and neurocognitive …
Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of …
P Sinha, A Spicer, KL Delucchi, DF McAuley… - …, 2021 - thelancet.com
Abstract Background Heterogeneity in Acute Respiratory Distress Syndrome (ARDS), as a
consequence of its non-specific definition, has led to a multitude of negative randomised …
consequence of its non-specific definition, has led to a multitude of negative randomised …