Measuring allostatic load: Approaches and limitations to algorithm creation

JT Carbone, J Clift, N Alexander - Journal of Psychosomatic Research, 2022 - Elsevier
Objective Allostatic load literature has proliferated over the past three decades, and a
growing body of research demonstrates that higher levels of allostatic load are associated …

[HTML][HTML] AI and machine learning in resuscitation: ongoing research, new concepts, and key challenges

Y Okada, M Mertens, N Liu, SSW Lam, MEH Ong - Resuscitation plus, 2023 - Elsevier
Aim Artificial intelligence (AI) and machine learning (ML) are important areas of computer
science that have recently attracted attention for their application to medicine. However, as …

Latent class analysis reveals COVID-19–related acute respiratory distress syndrome subgroups with differential responses to corticosteroids

P Sinha, D Furfaro, MJ Cummings… - American journal of …, 2021 - atsjournals.org
Rationale: Two distinct subphenotypes have been identified in acute respiratory distress
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …

Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials

P Sinha, VE Kerchberger, A Willmore… - The Lancet …, 2023 - thelancet.com
Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

LDJ Bos, M Sjoding, P Sinha, SV Bhavani… - The lancet Respiratory …, 2021 - thelancet.com
Background Patients with COVID-19-related acute respiratory distress syndrome (ARDS)
have been postulated to present with distinct respiratory subphenotypes. However, most …

Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis

MK Dahmer, G Yang, M Zhang… - The Lancet …, 2022 - thelancet.com
Background Previous latent class analysis of adults with acute respiratory distress syndrome
(ARDS) identified two phenotypes, distinguished by the degree of inflammation. We aimed …

Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study

P Sinha, KL Delucchi, Y Chen, H Zhuo, J Abbott… - Thorax, 2022 - thorax.bmj.com
Rationale Using latent class analysis (LCA), two subphenotypes of acute respiratory distress
syndrome (ARDS) have consistently been identified in five randomised controlled trials …

The prevalence of MAFLD and its association with atrial fibrillation in a nationwide health check-up population in China

F Lei, JJ Qin, X Song, YM Liu, MM Chen… - Frontiers in …, 2022 - frontiersin.org
Background and aims The epidemiological characteristics of MAFLD and its relationship
with atrial fibrillation (AF) are limited in China. Therefore, we explored the epidemiological …

Associations of symptom clusters and health outcomes in adult survivors of childhood cancer: A report from the St Jude lifetime cohort study

H Shin, WN Dudley, N Bhakta, MR Horan… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To identify symptom clusters among adult survivors of childhood cancers and test
associations with health-related quality of life (HRQOL) and physical and neurocognitive …

Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of …

P Sinha, A Spicer, KL Delucchi, DF McAuley… - …, 2021 - thelancet.com
Abstract Background Heterogeneity in Acute Respiratory Distress Syndrome (ARDS), as a
consequence of its non-specific definition, has led to a multitude of negative randomised …