Development of Chromosome 1q+ Specific Treatment for Highest Risk Pediatric Posterior Fossa Ependymoma
AM Griesinger, AJ Calzadilla, E Grimaldo… - Clinical Cancer …, 2024 - AACR
Purpose: There are no effective treatment strategies for children with highest-risk posterior
fossa group A ependymoma (PFA). Chromosome 1q gains (1q+) are present in …
fossa group A ependymoma (PFA). Chromosome 1q gains (1q+) are present in …
No safe harbors for recurrent posterior fossa group A ependymoma: A time for change in risk assignment?
JR Hansford, DD Eisenstat - Neuro-oncology, 2023 - academic.oup.com
Editorial 1869 treatment-resistant, undifferentiated neuroepithelial progenitor-like cell (UEC-
A) group that is selected for the high-risk patients at relapse. Furthermore, IHC scoring of …
A) group that is selected for the high-risk patients at relapse. Furthermore, IHC scoring of …
Developing targeted therapies for pediatric PFA ependymoma
AL Jenseit - 2024 - archiv.ub.uni-heidelberg.de
PFA ependymomas are highly aggressive brain tumors typically arising in young children
(median age 3 years) and characterized by a poor outcome (10-year OS< 60%). Standard of …
(median age 3 years) and characterized by a poor outcome (10-year OS< 60%). Standard of …
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RJ Packer - medlink.com
Medulloblastoma is the most common malignant childhood brain tumor. There has been a
marked improvement in overall survival for patients with this tumor, but a major challenge …
marked improvement in overall survival for patients with this tumor, but a major challenge …
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
S Gödicke, C Kresbach, M Ehlert, D Obrecht… - Acta …, 2024 - Springer
Posterior fossa type A (PF-EPN-A, PFA) ependymoma are aggressive tumors that mainly
affect children and have a poor prognosis. Histopathology shows significant intratumoral …
affect children and have a poor prognosis. Histopathology shows significant intratumoral …