Microenvironment imbalance of spinal cord injury

B Fan, Z Wei, X Yao, G Shi, X Cheng… - Cell …, 2018 - journals.sagepub.com
Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …

Targeting neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury

KM Keefe, IS Sheikh, GM Smith - International journal of molecular …, 2017 - mdpi.com
Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …

[HTML][HTML] Stem cell treatment of degenerative eye disease

B Mead, M Berry, A Logan, RAH Scott, W Leadbeater… - Stem cell …, 2015 - Elsevier
Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …

Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers

AK Varma, A Das, G Wallace, J Barry… - Neurochemical …, 2013 - Springer
The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than
10,000 per year, resulting in 720 cases per million persons enduring permanent disability …

Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis

M Yousefifard, V Rahimi-Movaghar, F Nasirinezhad… - Neuroscience, 2016 - Elsevier
Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum
protocol has been developed for application of neural stem/progenitor cells. In this regard …

Transplantation of induced pluripotent stem cell-derived neural stem cells mediate functional recovery following thoracic spinal cord injury through remyelination of …

RP Salewski, RA Mitchell, L Li, C Shen… - Stem cells …, 2015 - academic.oup.com
Neural stem cells (NSCs) from embryonic or fetal/adult tissue sources have shown
considerable promise in regenerative strategies for traumatic spinal cord injury (SCI) …

Functional recovery from neural stem/progenitor cell transplantation combined with treadmill training in mice with chronic spinal cord injury

S Tashiro, S Nishimura, H Iwai, K Sugai, L Zhang… - Scientific Reports, 2016 - nature.com
Most studies targeting chronic spinal cord injury (SCI) have concluded that neural
stem/progenitor cell (NS/PC) transplantation exerts only a subclinical recovery; this in …

Neurotrophic factors for spinal cord repair: Which, where, how and when to apply, and for what period of time?

AR Harvey, SJ Lovett, BT Majda, JH Yoon… - Brain research, 2015 - Elsevier
A variety of neurotrophic factors have been used in attempts to improve morphological and
behavioural outcomes after experimental spinal cord injury (SCI). Here we review many of …

Neurotrophic factors used to treat spinal cord injury

SI Hodgetts, AR Harvey - Vitamins and hormones, 2017 - Elsevier
The application of neurotrophic factors as a therapy to improve morphological and
behavioral outcomes after experimental spinal cord injury (SCI) has been the focus of many …

Sustained delivery of neurotrophic factors to treat spinal cord injury

A Muheremu, L Shu, J Liang, A Aili… - Translational …, 2021 - degruyter.com
Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical
and psychological harm and a series of socioeconomic problems. Although neurons in the …