Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Rationale: Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing
significant vision loss. DR is a multifactorial disease involving changes in retinal …

The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine
tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory …

Contactins (CNTNs) are neural cell adhesion molecules that encode axon-target specificity
during the patterning of the vertebrate visual and olfactory systems. Because CNTNs are …

The identification of factors that regulate myelination provides important insight into the
molecular mechanisms that coordinate nervous system development and myelin …

Abstract Integral Membrane Protein 2 B (ITM2B) is a type II ubiquitous transmembrane
protein which role remains unclear. ITM2B mutations have been associated with different …

The aqueous environment is a pervasive factor which, in many ways, determines the protein
folding process and consequently the activity of proteins. Proteins are unable to perform …

The amyloid precursor–like protein 2 (APLP2) molecule is a type I transmembrane protein
that is crucial for survival, cell‐cell adhesion, neuronal development, myelination, cancer …

Recent studies using animal models indicated that the members of the amyloid precursor
protein (APP) gene family are important for the formation, maintenance, and plasticity of …

Motor neurone disease (MND) is a neurodegenerative disorder characterised by
progressive destruction of motor neurons, muscle paralysis and death. The amyloid …