Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely
contributing to tumor immune evasion. The deregulation mainly arises from the potentiated …

Over the past 25 years, research in cancer therapeutics has largely focused on two distinct
lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous …

We conducted a pilot clinical trial testing a personalized vaccine generated by autologous
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC) …

Abstract Sipuleucel-T (PROVENGE; Dendreon) is the first therapeutic cancer vaccine to be
approved by the US Food and Drug Administration. In men who have metastatic castration …

Dendritic cells (DCs) are considered as professional antigen presenting cells (APCs),
containing a variety of subsets, that can be resident in organs or migrating among the …

Tumors evade the immune system though a myriad of mechanisms. Using checkpoint
inhibitors to help reprime T cells to recognize tumor has had great success in malignancies …

Sipuleucel-T, an autologous cellular immunotherapy manufactured from antigen-presenting
cells primed to recognize prostatic acid phosphatase, was the first immunotherapy product …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer,
gastric cancer, and/or glioblastoma includes administering to said patient a composition …

The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …