When tissue is subjected to higher than physiological temperatures, protein and cell
organelle structures can be altered resulting in cell death and subsequent tissue necrosis. A …

Animal toxins present a major threat to human health worldwide, predominantly through
snakebite envenomings, which are responsible for over 100,000 deaths each year. To date …

The SH3 domain, comprised of approximately 60 residues, is found within a wide variety of
proteins, and is a mediator of protein–protein interactions. Due to the large number of SH3 …

Most thermophilic proteins tend to have more salt bridges, and achieve higher
thermostability by up-shifting and broadening their protein stability curves. While the …

Here, we analyze the thermodynamic parameters and their correlations in families
containing homologous thermophilic and mesophilic proteins which show reversible two …

We have analyzed sequence covariation in an alignment of 266 non-redundant SH3 domain
sequences using chi-squared statistical methods. Artifactual covariations arising from close …

The generation of novel binding molecules based on protein frameworks (" scaffolds")
represents an emerging field in protein engineering, with the potential to replace antibodies …

We describe the physicochemical characterization of various circular and linear forms of
the∼ 60 residue N-terminal Src homology 3 (SH3) domain from the murine c-Crk adapter …

We have designed de novo 13 divergent spectrin SH3 core sequences to determine their
folding properties. Kinetic analysis of the variants with stability similar to that of the wild type …

We have determined the solution structures, equilibrium properties and ultra-fast folding
kinetics for three bacterial homologues of the peripheral subunit-binding domain (PSBD) …